6C48.3

ICD-11 MMS 2026-01

Caffeine withdrawal

Description

Caffeine withdrawal is a clinically significant cluster of symptoms, behaviours and/or physiological features, varying in degree of severity and duration, that occurs upon cessation or reduction of use of caffeine (typically in the form of coffee, caffeinated drinks, or as an ingredient in certain over-the-counter medications) in individuals who have used caffeine for a prolonged period or in large amounts. Presenting features of Caffeine withdrawal may include headache, marked fatigue or drowsiness, irritability, depressed or dysphoric mood, nausea or vomiting, and difficulty concentrating.

Index terms

  • Caffeine withdrawal

Exclusions from above levels

  • 6C46 – Disorders due to use of stimulants including amphetamines, methamphetamine or methcathinone
  • QE11.5 – Hazardous use of caffeine
  • QE62 – Uncomplicated bereavement
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  • QE84 – Acute stress reaction

Sibling codes

  • 6C48.0 – Episode of harmful use of caffeine
  • 6C48.1 – Harmful pattern of use of caffeine
  • 6C48.2 – Caffeine intoxication
  • 6C48.4 – Certain specified caffeine-induced mental or behavioural disorders
  • 6C48.Y – Other specified disorders due to use of caffeine
  • 6C48.Z – Disorders due to use of caffeine, unspecified

Foundation entity

Caffeine withdrawal – http://id.who.int/icd/entity/1569910443

Allowed postcoordination axes

Part of: 6C48: Disorders due to use of caffeine › 06: Mental, behavioural or neurodevelopmental disorders