8B60.0

ICD-11 MMS 2026-01

Amyotrophic lateral sclerosis

Description

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder in which progressive signs of LMN and UMN degeneration are seen within one or more of the four regions: bulbar, cervical, thoracic and lumbosacral. Electrophysiological studies may be required to confirm lower motor neuron degeneration and to exclude alternative causes. Neuroimaging may be performed to exclude other causes, which might explain the clinical and electrophysiological features. Familial ALS (FALS) of autosomal dominant inheritance constitutes 5 to 10% of ALS. The clinical profile of FALS and sporadic ALS is similar. Mutations in the C9ORF72 and Cu/Zn superoxide dismutase (SOD1) genes constitute 50-60% of FALS.

Index terms

  • Amyotrophic lateral sclerosis
  • ALS - [amyotrophic lateral sclerosis]
  • amyotrophic paralysis
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  • amyotrophic sclerosis
  • amyotrophy lateral sclerosis
  • progressive atrophic paralysis
  • spinal progressive amyotrophy

Exclusions from above levels

  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 19 – Certain conditions originating in the perinatal period
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  • 22 – Injury, poisoning or certain other consequences of external causes

Sibling codes

  • 8B60.1 – Progressive bulbar palsy
  • 8B60.2 – Progressive pseudobulbar palsy
  • 8B60.3 – Progressive muscular atrophy
  • 8B60.4 – Primary lateral sclerosis
  • 8B60.5 – Amyotrophic lateral sclerosis-Plus
  • 8B60.6 – Monomelic amyotrophy
  • 8B60.7 – Madras type motor neuron disease
  • 8B60.Y – Other specified motor neuron disease
  • 8B60.Z – Motor neuron disease, unspecified

Foundation entity

Amyotrophic lateral sclerosis – http://id.who.int/icd/entity/1982355687

Allowed postcoordination axes

Part of: 8B60: Motor neuron disease › 08: Diseases of the nervous system