8C62

ICD-11 MMS 2026-01

Lambert-Eaton syndrome

Description

Lambert-Eaton myasthenic syndrome, 20 times as rare as acetylcholine receptor positive myasthenia gravis with a prevalence of 3.42 per million, is an immune-mediated disease of the neuromuscular junction. Clinically the disease is characterised by proximal weakness of the legs. In most patients, the weakness extends to other muscles including the oculobulbar ones. Autonomic symptoms (dry mouth, erectile dysfunction, constipation) are frequent. Tendon reflexes are reduced. Repetitive nerve stimulation shows low compound muscle action potentials, decrement > 10% at low frequency and increment > 100% after maximum voluntary contraction at high frequency.

Index terms

  • Lambert-Eaton syndrome
  • Eaton-Lambert syndrome
  • LEMS - [Lambert-Eaton myasthenic syndrome]
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  • Lambert-Eaton myasthenic syndrome
  • Paraneoplastic Lambert Eaton syndrome
  • Lambert-Eaton syndrome, malignancy association
  • Paraneoplastic Lambert Eaton myasthenic syndrome
  • Voltage-gated calcium channel-associated Lambert-Eaton myasthenic syndrome
  • Myasthenic-Myopathic syndrome of Lambert-Eaton
  • SOX-associated Lambert-Eaton myasthenic syndrome
  • Lambert-Eaton syndrome, autoimmune-acquired
  • Lambert-Eaton myasthenic syndrome, antibody positive
  • Lambert-Eaton syndrome, antibody positive

Exclusions from above levels

  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 19 – Certain conditions originating in the perinatal period
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  • 22 – Injury, poisoning or certain other consequences of external causes

Sibling codes

  • 8C60 – Myasthenia gravis
  • 8C61 – Congenital myasthenic syndromes
  • 8C6Y – Other specified neuromuscular junction disorders
  • 8C6Z – Neuromuscular junction disorders, unspecified

Foundation entity

Lambert-Eaton syndrome – http://id.who.int/icd/entity/796417193

Part of: 08: Diseases of the nervous system