Myasthenia gravis

Description

Myasthenia gravis is the most common acquired auto-antibody mediated neuromuscular transmission disorder. Prevalence is 1–2 per 10,000 persons. Fluctuating weakness increasing with repeated activity and improving after a period of rest is the hallmark. Myasthenia Gravis with antibodies directed against postsynaptic proteins, usually the nicotinic acetylcholine receptor are the most prevalent. Other types are Myasthenia Gravis associated with muscle-specific kinase antibodies and MG with unknown autoantibodies (seronegative) Myasthenia Gravis. There are three groups: 1. Purely ocular Myasthenia Gravis 2. Early-onset (<40-50 years) generalised Myasthenia Gravis 3. Late-onset generalised MG. In about 15%, the disease can be classified as paraneoplastic, usually associated with a thymoma.

Exclusions from above levels

• 05 – Endocrine, nutritional or metabolic diseases
• 18 – Complications of pregnancy, childbirth and the puerperium
• 19 – Certain conditions originating in the perinatal period