DB99.5

ICD-11 MMS 2026-01

Hepatic encephalopathy

Description

Hepatic encephalopathy is a complication of liver cirrhosis and a hallmark of acute liver failure, and is also observed in patients with portosystemic shunts without cirrhosis. Hepatic encephalopathy is characterised by personality changes, intellectual impairment, flapping tremor and a decreased consciousness level. In the advanced stages it is called hepatic coma, which may lead to death. The diagnosis of hepatic encephalopathy is made primarily by recognition of neuropsychiatric changes occurring in a patient with liver disease, after exclusion of brain diseases.

Index terms

  • Hepatic encephalopathy
  • HE - [hepatic encephalopathy]
  • hepatic encephalopathy NOS
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  • hepatic encephalopathy, stage unspecified
  • hepatocerebral encephalopathy
  • hepatocerebral intoxication
  • metabolic hepatic encephalopathy
  • portal-systemic encephalopathy
  • portosystemic encephalopathy
  • Hepatic encephalopathy, stage 1
  • Hepatic encephalopathy, stage 2
  • Hepatic encephalopathy, stage 3
  • Hepatic encephalopathy, stage 4
  • Acute hepatic encephalopathy
  • acute hepatoencephalopathy
  • Acute hepatorenal encephalopathy
  • acute hepatorenal coma
  • Acute portosystemic encephalopathy
  • Gaustad's syndrome
  • Transient hepatargy syndrome
  • Hepatic encephalopathy, minimal
  • Covert hepatic encephalopathy
  • MHE - [Minimal hepatic encephalopathy]
  • Hepatic coma

Excludes

  • DB99.0 – Chronic liver disease

Exclusions from above levels

  • 5D00.0 – amyloid degeneration of liver
  • BD71.Y – hepatic vein thrombosis
  • DB94 – alcoholic liver disease
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  • DB95 – toxic liver disease
  • DB98.3 – portal vein thrombosis
  • LB20.00 – cystic disease of liver (congenital)
  • ME10.00 – hepatomegaly NOS
  • ME10.1 – Unspecified jaundice
  • 01 – Certain infectious or parasitic diseases
  • 02 – Neoplasms
  • 05 – Endocrine, nutritional or metabolic diseases
  • 06 – Mental, behavioural or neurodevelopmental disorders
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 22 – Injury, poisoning or certain other consequences of external causes

Sibling codes

  • DB99.0 – Chronic liver disease
  • DB99.1 – Hepatic cyst
  • DB99.2 – Hepatorenal syndrome
  • DB99.3 – Portopulmonary hypertension
  • DB99.4 – Hepatopulmonary syndrome
  • DB99.6 – Intrahepatic cholestasis, not elsewhere classified
  • DB99.7 – Hepatic failure without mention whether acute or chronic
  • DB99.8 – Chronic hepatic failure
  • DB99.Y – Other specified diseases of liver

Foundation entity

Hepatic encephalopathy – http://id.who.int/icd/entity/1769383160

Allowed postcoordination axes

Part of: DB99: Certain specified diseases of liver › 13: Diseases of the digestive system