4A45

ICD-11 MMS 2026-01

Antiphospholipid syndrome

Description

Antiphospholipid syndrome, also known as Hughes syndrome, is a systemic autoimmune condition characterised by the presence of antiphospholipid antibodies (aPL) in the serum of patients with thrombotic events and/or recurrent pregnancy complications.

Exclusions from above levels

  • 02 – Neoplasms
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 20 – Developmental anomalies

Child codes

  • 4A45.0 – Primary antiphospholipid syndrome
  • 4A45.1 – Secondary antiphospholipid syndrome
  • 4A45.2 – Antiphospholipid syndrome in pregnancy
  • 4A45.3 – Lupus anticoagulant-hypoprothrombinaemia syndrome
  • 4A45.Z – Antiphospholipid syndrome, unspecified

Sibling codes

  • 4A40 – Lupus erythematosus
  • 4A41 – Idiopathic inflammatory myopathy
  • 4A42 – Systemic sclerosis
  • 4A43 – Overlap or undifferentiated nonorgan specific systemic autoimmune disease
  • 4A44 – Vasculitis
  • 4A4Y – Other specified nonorgan specific systemic autoimmune disorders
  • 4A4Z – Nonorgan specific systemic autoimmune disorders, unspecified

Foundation entity

Antiphospholipid syndrome – http://id.who.int/icd/entity/1173370808

Part of: 04: Diseases of the immune system