8A41

ICD-11 MMS 2026-01

Isolated demyelinating syndromes of the central nervous system

Description

Isolated demyelinating syndromes of the central nervous system (also known as Clinically isolated syndrome (CIS)) is the first clinical inflammatory demyelinating event of the central nervous system, lasting more than 24 hours. CIS is now recognised as the first clinical presentation of a disease that shows characteristics of inflammatory demyelination that could be Multiple sclerosis (MS), but has yet to fulfill criteria of dissemination in time.

Exclusions from above levels

  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 19 – Certain conditions originating in the perinatal period
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  • 22 – Injury, poisoning or certain other consequences of external causes

Child codes

  • 8A41.0 – Transverse myelitis
  • 8A41.1 – Neuromyelitis optica myelin oligodendrocyte glycoprotein antibody-positive
  • 8A41.Y – Other specified isolated demyelinating syndromes of the central nervous system
  • 8A41.Z – Isolated demyelinating syndromes of the central nervous system, unspecified

Foundation children elsewhere

Sibling codes

  • 8A40 – Multiple sclerosis
  • 8A42 – Acute disseminated encephalomyelitis
  • 8A43 – Neuromyelitis optica
  • 8A44 – Leukodystrophies
  • 8A45 – Secondary white matter disorders
  • 8A46 – Central demyelination of corpus callosum
  • 8A4Y – Other specified multiple sclerosis or other white matter disorders
  • 8A4Z – Multiple sclerosis or other white matter disorders, unspecified

Foundation entity

Isolated demyelinating syndromes of the central nervous system – http://id.who.int/icd/entity/1690813510

Part of: 08: Diseases of the nervous system