Follicular lymphoma

Description

Follicular lymphoma (FL) is a neoplasm composed of follicle centre (germinal centre) B-cells (typically both centrocytes and centroblasts/large transformed cells), which usually has at least a partially follicular pattern. t(14;18) with BCL2 rearrangement is frequently observed. If diffuse areas of any size comprised predominantly or entirely of blastic cells are present in any case of follicular lymphoma, a diagnosis of diffuse large B-cell lymphoma is also made. Lymphomas composed of centro cytes and centroblasts with an entirely diffuse pattern in the sampled tissue may be included in this category.

Inclusions

follicular lymphoma with or without diffuse areas

Excludes

http://id.who.int/icd/entity/450630526 – Mature T-cell or NK-cell neoplasms

Exclusions from above levels

2E03 – Malignant neoplasm metastasis in bone or bone marrow
http://id.who.int/icd/entity/501778925 – Malignant neoplasm metastasis in lymph nodes
http://id.who.int/icd/entity/97145147 – Malignant neoplasm metastasis in thymus gland

Child codes

2A80.0 – Follicular lymphoma grade 1
2A80.1 – Follicular lymphoma grade 2
2A80.2 – Follicular lymphoma grade 3
2A80.3 – Primary cutaneous follicle centre lymphoma
2A80.4 – Paediatric type follicular lymphoma
2A80.5 – Follicular lymphoma in situ
2A80.6 – Follicular lymphoma of small intestine
2A80.Y – Other specified follicular lymphoma
2A80.Z – Follicular lymphoma, unspecified

Sibling codes

2A81 – Diffuse large B-cell lymphomas
2A82 – Mature B-cell neoplasm with leukaemic behaviour
2A83 – Plasma cell neoplasms
2A84 – Heavy chain diseases or malignant immunoproliferative diseases
2A85 – Other specified mature B-cell neoplasms or lymphoma
2A86 – B-cell lymphoma, mixed features
2A8Z – Mature B-cell neoplasms, unspecified

Foundation entity

Follicular lymphoma – http://id.who.int/icd/entity/797822185

Allowed postcoordination axes

hasManifestation

Part of: 02: Neoplasms