2A83

ICD-11 MMS 2026-01

Plasma cell neoplasms

Description

Plasma cell neoplasms are a group of disorders characterized by the monoclonal expansion of terminally differentiated B cells (plasma cells) that produce monoclonal immunoglobulins, known as M proteins or paraproteins. Key types include plasma cell myeloma (multiple myeloma), plasmacytoma, and neoplasms associated with paraneoplastic syndromes like POEMS syndrome.

Exclusions from above levels

  • 2E03 – Malignant neoplasm metastasis in bone or bone marrow
  • http://id.who.int/icd/entity/501778925 – Malignant neoplasm metastasis in lymph nodes
  • http://id.who.int/icd/entity/97145147 – Malignant neoplasm metastasis in thymus gland

Child codes

  • 2A83.0 – Monoclonal gammopathy of undetermined significance
  • 2A83.1 – Plasma cell myeloma
  • 2A83.2 – Solitary plasmacytoma
  • 2A83.3 – Extraosseous plasmacytoma
  • 2A83.4 – Plasma cell leukaemia
  • 2A83.5 – Monoclonal immunoglobulin deposition disease
  • 2A83.Y – Other specified plasma cell neoplasms
  • 2A83.Z – Plasma cell neoplasm, unspecified

Sibling codes

  • 2A80 – Follicular lymphoma
  • 2A81 – Diffuse large B-cell lymphomas
  • 2A82 – Mature B-cell neoplasm with leukaemic behaviour
  • 2A84 – Heavy chain diseases or malignant immunoproliferative diseases
  • 2A85 – Other specified mature B-cell neoplasms or lymphoma
  • 2A86 – B-cell lymphoma, mixed features
  • 2A8Z – Mature B-cell neoplasms, unspecified

Foundation entity

Plasma cell neoplasms – http://id.who.int/icd/entity/1219149360

Allowed postcoordination axes

Part of: 02: Neoplasms