2A81.8

ICD-11 MMS 2026-01

ALK-positive large B-cell lymphoma

Description

A usually aggressive large B-cell lymphoma characterised by the presence of monomorphic immunoblast-like neoplastic B-lymphocytes in a sinusoidal growth pattern. The neoplastic B-lymphocytes express the ALK kinase but they lack the 2;5 translocation.

Index terms

  • ALK-positive large B-cell lymphoma
  • Diffuse large B-cell lymphoma, ALK positive

Exclusions from above levels

  • 2E03 – Malignant neoplasm metastasis in bone or bone marrow
  • http://id.who.int/icd/entity/501778925 – Malignant neoplasm metastasis in lymph nodes
  • http://id.who.int/icd/entity/97145147 – Malignant neoplasm metastasis in thymus gland

Sibling codes

  • 2A81.0 – Primary mediastinal large B-cell lymphoma
  • 2A81.1 – Intravascular large B-cell lymphoma
  • 2A81.2 – Plasmablastic lymphoma
  • 2A81.3 – Lymphomatoid granulomatosis
  • 2A81.4 – T-cell/histiocyte rich large B-cell lymphoma
  • 2A81.5 – Primary diffuse large B-cell lymphoma of central nervous system
  • 2A81.6 – Epstein-Barr Virus-positive diffuse large B-cell lymphoma of the elderly
  • 2A81.7 – Diffuse large B-cell lymphoma associated with chronic inflammation
  • 2A81.9 – Primary effusion lymphoma
  • 2A81.A – Primary cutaneous diffuse large B-cell lymphoma, leg type
  • 2A81.Y – Other specified diffuse large B-cell lymphomas
  • 2A81.Z – Diffuse large B-cell lymphoma, not otherwise specified

Foundation entity

ALK-positive large B-cell lymphoma – http://id.who.int/icd/entity/2077559619

Allowed postcoordination axes

Part of: 2A81: Diffuse large B-cell lymphomas › 02: Neoplasms