2A81.A

ICD-11 MMS 2026-01

Primary cutaneous diffuse large B-cell lymphoma, leg type

Description

An aggressive primary cutaneous B-cell lymphoma, usually involving the lower leg. It is composed of a generally monotonous proliferation of immunoblasts, or less frequently centroblasts, with few admixed reactive cells. This type of lymphoma occurs most often in the elderly who present with rapidly growing tumours, usually on one or both legs. Dissemination to extracutaneous sites is frequent.

Index terms

  • Primary cutaneous diffuse large B-cell lymphoma, leg type

Exclusions from above levels

  • 2E03 – Malignant neoplasm metastasis in bone or bone marrow
  • http://id.who.int/icd/entity/501778925 – Malignant neoplasm metastasis in lymph nodes
  • http://id.who.int/icd/entity/97145147 – Malignant neoplasm metastasis in thymus gland

Sibling codes

  • 2A81.0 – Primary mediastinal large B-cell lymphoma
  • 2A81.1 – Intravascular large B-cell lymphoma
  • 2A81.2 – Plasmablastic lymphoma
  • 2A81.3 – Lymphomatoid granulomatosis
  • 2A81.4 – T-cell/histiocyte rich large B-cell lymphoma
  • 2A81.5 – Primary diffuse large B-cell lymphoma of central nervous system
  • 2A81.6 – Epstein-Barr Virus-positive diffuse large B-cell lymphoma of the elderly
  • 2A81.7 – Diffuse large B-cell lymphoma associated with chronic inflammation
  • 2A81.8 – ALK-positive large B-cell lymphoma
  • 2A81.9 – Primary effusion lymphoma
  • 2A81.Y – Other specified diffuse large B-cell lymphomas
  • 2A81.Z – Diffuse large B-cell lymphoma, not otherwise specified

Foundation entity

Primary cutaneous diffuse large B-cell lymphoma, leg type – http://id.who.int/icd/entity/1418101362

Allowed postcoordination axes

Part of: 2A81: Diffuse large B-cell lymphomas › 02: Neoplasms