2B51

ICD-11 MMS 2026-01

Osteosarcoma, primary site

Description

A usually aggressive malignant bone-forming mesenchymal tumour, predominantly affecting adolescents and young adults. It usually involves bones and less frequently extraosseous sites. It often involves the long bones (particularly distal femur, proximal tibia, and proximal humerus). Pain with or without a palpable mass is the most frequent clinical symptom. It may spread to other anatomic sites, particularly the lungs.

Coding note from above levels

For use of this category, reference should be made to the mortality coding rules and guidelines in the Reference Guide.

Exclusions from above levels

  • 2A01.1 – Mesenchymal tumour of meninges
  • 2A02.1 – Tumours of cranial or paraspinal nerves
  • http://id.who.int/icd/entity/879154182 – Neoplasms of central nervous system or related structures
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  • http://id.who.int/icd/entity/944754984 – Neoplasms of haematopoietic or lymphoid tissues

Child codes

  • 2B51.0 – Osteosarcoma of bone or articular cartilage of jaw
  • 2B51.1 – Osteosarcoma of bone or articular cartilage of limbs
  • 2B51.2 – Osteosarcoma of bone or articular cartilage of pelvis
  • 2B51.Y – Osteosarcoma of bone or articular cartilage of other specified sites
  • 2B51.Z – Osteosarcoma of bone or articular cartilage of unspecified sites

Sibling codes

  • 2B50 – Chondrosarcoma, primary site
  • 2B52 – Ewing sarcoma, primary site
  • 2B53 – Fibroblastic or myofibroblastic tumour, primary site
  • 2B54 – Undifferentiated pleomorphic sarcoma, primary site
  • 2B55 – Rhabdomyosarcoma, primary site
  • 2B56 – Angiosarcoma, primary site
  • 2B57 – Kaposi sarcoma, primary site
  • 2B58 – Leiomyosarcoma, primary site
  • 2B59 – Liposarcoma, primary site
  • 2B5A – Synovial sarcoma, primary site
  • 2B5B – Gastrointestinal stromal tumour, primary site
  • 2B5C – Endometrial stromal sarcoma, primary site
  • 2B5D – Malignant mixed epithelial mesenchymal tumour, primary site
  • 2B5E – Malignant nerve sheath tumour of peripheral nerves or autonomic nervous system, primary site
  • 2B5F – Sarcoma, not elsewhere classified, primary site
  • 2B5G – Myosarcoma of uterus, part not specified
  • 2B5H – Well differentiated lipomatous tumour, primary site
  • 2B5J – Malignant miscellaneous tumours of bone or articular cartilage of other or unspecified sites
  • 2B5K – Unspecified malignant soft tissue tumours or sarcomas of bone or articular cartilage of other or unspecified sites
  • 2B5Y – Other specified malignant mesenchymal neoplasms
  • 2B5Z – Malignant mesenchymal neoplasm of unspecified type

Foundation entity

Osteosarcoma, primary site – http://id.who.int/icd/entity/1210287093

Allowed postcoordination axes

Part of: 02: Neoplasms