Gastrointestinal stromal tumour, primary site

Description

This is the most common mesenchymal tumour that arises in the gastrointestinal tract. It is generally immunohistochemically positive for CD117 (KIT), phenotypically paralleling Cajal-cell differentiation, and most examples contain KIT- or PDGFRA-activating mutations. It is most frequent in the stomach and to a lesser degree in the small intestine. The prognosis depends on the tumour size and the mitotic activity.

Coding note from above levels

For use of this category, reference should be made to the mortality coding rules and guidelines in the Reference Guide.

Exclusions from above levels

2A01.1 – Mesenchymal tumour of meninges
2A02.1 – Tumours of cranial or paraspinal nerves
http://id.who.int/icd/entity/879154182 – Neoplasms of central nervous system or related structures

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http://id.who.int/icd/entity/944754984 – Neoplasms of haematopoietic or lymphoid tissues

Child codes

2B5B.0 – Gastrointestinal stromal tumour of stomach
2B5B.1 – Gastrointestinal stromal tumour of small intestine
2B5B.Y – Gastrointestinal stromal tumour of other gastrointestinal sites
2B5B.Z – Gastrointestinal stromal tumour of unspecified gastrointestinal sites

Sibling codes

2B50 – Chondrosarcoma, primary site
2B51 – Osteosarcoma, primary site
2B52 – Ewing sarcoma, primary site
2B53 – Fibroblastic or myofibroblastic tumour, primary site
2B54 – Undifferentiated pleomorphic sarcoma, primary site
2B55 – Rhabdomyosarcoma, primary site
2B56 – Angiosarcoma, primary site
2B57 – Kaposi sarcoma, primary site
2B58 – Leiomyosarcoma, primary site
2B59 – Liposarcoma, primary site
2B5A – Synovial sarcoma, primary site
2B5C – Endometrial stromal sarcoma, primary site
2B5D – Malignant mixed epithelial mesenchymal tumour, primary site
2B5E – Malignant nerve sheath tumour of peripheral nerves or autonomic nervous system, primary site
2B5F – Sarcoma, not elsewhere classified, primary site
2B5G – Myosarcoma of uterus, part not specified
2B5H – Well differentiated lipomatous tumour, primary site
2B5J – Malignant miscellaneous tumours of bone or articular cartilage of other or unspecified sites
2B5K – Unspecified malignant soft tissue tumours or sarcomas of bone or articular cartilage of other or unspecified sites
2B5Y – Other specified malignant mesenchymal neoplasms
2B5Z – Malignant mesenchymal neoplasm of unspecified type

Foundation entity

Gastrointestinal stromal tumour, primary site – http://id.who.int/icd/entity/819644414

Allowed postcoordination axes

Part of: 02: Neoplasms