5B5F

ICD-11 MMS 2026-01

Vitamin B12 deficiency

Description

Vegetarianism and poverty-imposed near-vegetarianism are the most common causes of nutritional cobalamin insufficiency worldwide in all age groups. In such populations, low maternal cobalamin status is associated with adverse pregnancy outcomes (preterm birth, intrauterine growth retardation, early recurrent miscarriage), neural tube defects, reduced neurocognitive performance in children, accelerated bone turnover, and low bone mineral density with fractures. Insufficient cobalamin intake is also seen in breast-fed infants of mothers with pernicious anaemia.

Index terms

  • Vitamin B12 deficiency
  • cobalamin deficiency
  • cyanocobalamin deficiency
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  • deficiency of vitamin b12
  • Peripheral neuropathy due to vitamin B12 deficiency
  • Peripheral neuropathy due to cobalamin deficiency
  • Myelopathy due to vitamin B12 deficiency
  • myelopathy due to cobalamin deficiency
  • Encephalopathy due to vitamin B12 deficiency
  • Optic neuropathy due to vitamin B12 deficiency

Inclusions

  • cobalamin deficiency
  • cyanocobalamin deficiency

Exclusions from above levels

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  • NF07.0 – starvation
  • 18 – Pregnancy, childbirth or the puerperium
  • http://id.who.int/icd/entity/1004987305 – Transitory endocrine or metabolic disorders specific to fetus or newborn

Foundation children elsewhere

  • 3A01.2 – Vitamin B12 deficiency anaemia due to low intake
  • 3A01.3 – Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
  • 3A01.4 – Vitamin B12 deficiency anaemia due to intestinal disease
  • 3A01.5 – Drug-induced vitamin B12 deficiency anaemia

Sibling codes

  • 5B50 – Underweight in infants, children or adolescents
  • 5B51 – Wasting in infants, children or adolescents
  • 5B52 – Acute malnutrition in infants, children or adolescents
  • 5B53 – Stunting in infants, children or adolescents
  • 5B54 – Underweight in adults
  • 5B55 – Vitamin A deficiency
  • 5B56 – Vitamin C deficiency
  • 5B57 – Vitamin D deficiency
  • 5B58 – Vitamin E deficiency
  • 5B59 – Vitamin K deficiency
  • 5B5A – Vitamin B1 deficiency
  • 5B5B – Vitamin B2 deficiency
  • 5B5C – Vitamin B3 deficiency
  • 5B5D – Vitamin B6 deficiency
  • 5B5E – Folate deficiency
  • 5B5G – Biotin deficiency
  • 5B5H – Pantothenic acid deficiency
  • 5B5J – Choline deficiency
  • 5B5K – Mineral deficiencies
  • 5B70 – Essential fatty acid deficiency
  • 5B71 – Protein deficiency
  • 5B7Y – Other specified undernutrition
  • 5B7Z – Unspecified undernutrition

Foundation entity

Vitamin B12 deficiency – http://id.who.int/icd/entity/1366882206

Allowed postcoordination axes

Part of: 05: Endocrine, nutritional or metabolic diseases