5B5GICD-11 MMS 2026-01
Biotin deficiency
Description
Isolated biotin deficiency is rare. Signs of biotin deficiency in humans have been demonstrated in individuals who consume raw egg white over long periods and in total parenteral nutrition (TPN) before biotin supplementation in patients with malabsorption. The clinical findings of biotin deficiency include dermatitis, conjunctivitis, alopecia, and central nervous system abnormalities. In adults fed raw egg white (which contains avidin, a protein that binds biotin with such high affinity that it renders it biounavailable) or receiving biotin-free TPN for months to years, thinning of hair, frequently with loss of hair colour, has been reported. Most adults with the deficiency demonstrate a red, scaly, skin rash, frequently around the eyes, nose, and mouth. Most of the adults have neurological symptoms, including depression, lethargy, hallucinations, and paraesthesia of the extremities.
Index terms
- Biotin deficiency
- biotan vitamin deficiency
- biotin deficiency disease
Exclusions from above levels
Sibling codes
5B50– Underweight in infants, children or adolescents5B51– Wasting in infants, children or adolescents5B52– Acute malnutrition in infants, children or adolescents5B53– Stunting in infants, children or adolescents5B54– Underweight in adults5B55– Vitamin A deficiency5B56– Vitamin C deficiency5B57– Vitamin D deficiency5B58– Vitamin E deficiency5B59– Vitamin K deficiency5B5A– Vitamin B1 deficiency5B5B– Vitamin B2 deficiency5B5C– Vitamin B3 deficiency5B5D– Vitamin B6 deficiency5B5E– Folate deficiency5B5F– Vitamin B12 deficiency5B5H– Pantothenic acid deficiency5B5J– Choline deficiency5B5K– Mineral deficiencies5B70– Essential fatty acid deficiency5B71– Protein deficiency5B7Y– Other specified undernutrition5B7Z– Unspecified undernutrition
Foundation entity
Part of: 05: Endocrine, nutritional or metabolic diseases