CA21

ICD-11 MMS 2026-01

Emphysema

Description

Emphysema is defined by abnormal and permanent enlargement of the airspaces that are distal to the terminal bronchioles. This is accompanied by destruction of the airspace walls, without obvious fibrosis (i.e. there is no fibrosis visible to the naked eye). Emphysema can exist in individuals who do not have airflow obstruction; however, it is more common among patients who have moderate or severe airflow obstruction.

Excludes

  • CA22 – emphysema with chronic (obstructive) bronchitis
  • CA22.1 – emphysematous (obstructive) bronchitis
  • CA81.Y – emphysema due to inhalation of chemicals, gases, fumes or vapours
  • CB40.3 – emphysema mediastinal
  • CB40.4 – Compensatory emphysema
  • KB27.0 – Interstitial emphysema originating in the perinatal period
  • NE81 – emphysema, surgical (subcutaneous)
  • NF0A.7 – Traumatic subcutaneous emphysema, not elsewhere classified

Exclusions from above levels

  • 01 – Certain infectious or parasitic diseases
  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth and the puerperium
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  • 19 – Certain conditions originating in the perinatal period
  • 20 – Congenital malformations, deformations and chromosomal abnormalities
  • 22 – Injury, poisoning or certain other consequences of external causes

Child codes

  • CA21.0 – MacLeod syndrome
  • CA21.1 – Panlobular emphysema
  • CA21.2 – Centrilobular emphysema
  • CA21.Y – Other specified emphysema
  • CA21.Z – Emphysema, unspecified

Sibling codes

  • CA20 – Bronchitis
  • CA22 – Chronic obstructive pulmonary disease
  • CA23 – Asthma
  • CA24 – Bronchiectasis
  • CA25 – Cystic fibrosis
  • CA26 – Chronic bronchiolitis
  • CA27 – Tracheobronchitis
  • CA2Y – Other specified lower respiratory tract disease
  • CA2Z – Lower respiratory tract disease, unspecified

Foundation entity

Emphysema – http://id.who.int/icd/entity/1948124976

Part of: 12: Diseases of the respiratory system