CA21.2

ICD-11 MMS 2026-01

Centrilobular emphysema

Description

Centrilobular (centriacinar) emphysema begins in the respiratory bronchioles and spreads peripherally. This form is associated with long-standing cigarette smoking and predominantly involves the upper half of the lungs.

Index terms

  • Centrilobular emphysema
  • centriacinar emphysema
  • lung or pulmonary emphysema, centriacinar
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  • lung or pulmonary emphysema, centrilobular

Exclusions from above levels

  • CA22 – emphysema with chronic (obstructive) bronchitis
  • CA22.1 – emphysematous (obstructive) bronchitis
  • CA81.Y – emphysema due to inhalation of chemicals, gases, fumes or vapours
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  • CB40.3 – emphysema mediastinal
  • CB40.4 – Compensatory emphysema
  • KB27.0 – Interstitial emphysema originating in the perinatal period
  • NE81 – emphysema, surgical (subcutaneous)
  • NF0A.7 – Traumatic subcutaneous emphysema, not elsewhere classified
  • 01 – Certain infectious or parasitic diseases
  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth and the puerperium
  • 19 – Certain conditions originating in the perinatal period
  • 20 – Congenital malformations, deformations and chromosomal abnormalities
  • 22 – Injury, poisoning or certain other consequences of external causes

Sibling codes

  • CA21.0 – MacLeod syndrome
  • CA21.1 – Panlobular emphysema
  • CA21.Y – Other specified emphysema
  • CA21.Z – Emphysema, unspecified

Foundation entity

Centrilobular emphysema – http://id.who.int/icd/entity/748115804

Part of: CA21: Emphysema › 12: Diseases of the respiratory system