3A51.2

ICD-11 MMS 2026-01

Sickle cell disease with crisis

Description

Sickle cell crisis occurs when the sickle cells block blood flow, thus decreasing oxygen delivery to the tissues. This results in intense to severe pain in the extremities, lower back, abdomen, and chest. A crisis can be brought on by illness, stress, dehydration, exposure to temperature changes or high altitudes.

Index terms

  • Sickle cell disease with crisis
  • Hb S disease with mention of crisis
  • Hb-SS disease with crisis
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  • Hb-SS disease with vaso-occlusive pain
  • HbSS with crisis
  • haemoglobin SS disease with crisis
  • sickle cell crisis
  • sickle-cell anaemia with crisis
  • sickle-cell disorder with crisis
  • vaso-occlusive crisis
  • Sickle cell disease with crisis with acute chest syndrome
  • HbSS with crisis with acute chest syndrome
  • Sickle cell disease with crisis with splenic sequestration
  • HbSS with crisis with splenic sequestration
  • Sickle cell disease with crisis with fever
  • HbSS with crisis with fever

Inclusions

  • Hb-SS disease with crisis

Exclusions from above levels

  • 04 – Diseases of the immune system
  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth or the puerperium
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  • 19 – Certain conditions originating in the perinatal period
  • 20 – Congenital malformations, deformations or chromosomal abnormalities
  • 22 – Injury, poisoning or certain other consequences of external causes
  • http://id.who.int/icd/entity/1000704511 – Human immunodeficiency virus disease
  • JB64.1 – Other diseases of the blood or blood-forming organs or certain disorders involving the immune mechanism complicating pregnancy, childbirth or the puerperium

Sibling codes

  • 3A51.0 – Sickle cell trait
  • 3A51.1 – Sickle cell disease without crisis
  • 3A51.3 – Compound heterozygous sickling disorders without crisis
  • 3A51.4 – Compound heterozygous sickling disorders with crisis
  • 3A51.5 – Haemoglobin C disease
  • 3A51.6 – Haemoglobin D disease
  • 3A51.7 – High affinity haemoglobin
  • 3A51.8 – Low affinity haemoglobin
  • 3A51.9 – Haemoglobin O disease
  • 3A51.A – Haemoglobin E disease
  • 3A51.B – Haemoglobin C/beta thalassaemia compound heterozygosity
  • 3A51.Y – Other specified sickle cell disorders or other haemoglobinopathies
  • 3A51.Z – Sickle cell disorders or other haemoglobinopathies, unspecified

Foundation entity

Sickle cell disease with crisis – http://id.who.int/icd/entity/55071409

Allowed postcoordination axes

Part of: 3A51: Sickle cell disorders or other haemoglobinopathies › 03: Diseases of the blood or blood-forming organs