3A51.5

ICD-11 MMS 2026-01

Haemoglobin C disease

Description

A disease caused by the bi-parental gene that encodes for haemoglobin C. This disease is characterised by abnormal structure of one of the globin chains of the haemoglobin molecule. This disease may present with mild haemolytic anaemia, increased risk for gallstones, enlarged spleen, episodes of joint pain, and increased risk of infection. This disease is confirmed by identification of the haemoglobin C gene by genetic testing.

Index terms

  • Haemoglobin C disease
  • Homozygous HbC carriers
  • Homozygous (HbC/HbC, HbC/beta-thal and other)

Excludes

  • 3A50.4 – Hereditary persistence of fetal haemoglobin

Exclusions from above levels

  • 04 – Diseases of the immune system
  • 05 – Endocrine, nutritional or metabolic diseases
  • 18 – Complications of pregnancy, childbirth or the puerperium
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  • 19 – Certain conditions originating in the perinatal period
  • 20 – Congenital malformations, deformations or chromosomal abnormalities
  • 22 – Injury, poisoning or certain other consequences of external causes
  • http://id.who.int/icd/entity/1000704511 – Human immunodeficiency virus disease
  • JB64.1 – Other diseases of the blood or blood-forming organs or certain disorders involving the immune mechanism complicating pregnancy, childbirth or the puerperium

Sibling codes

  • 3A51.0 – Sickle cell trait
  • 3A51.1 – Sickle cell disease without crisis
  • 3A51.2 – Sickle cell disease with crisis
  • 3A51.3 – Compound heterozygous sickling disorders without crisis
  • 3A51.4 – Compound heterozygous sickling disorders with crisis
  • 3A51.6 – Haemoglobin D disease
  • 3A51.7 – High affinity haemoglobin
  • 3A51.8 – Low affinity haemoglobin
  • 3A51.9 – Haemoglobin O disease
  • 3A51.A – Haemoglobin E disease
  • 3A51.B – Haemoglobin C/beta thalassaemia compound heterozygosity
  • 3A51.Y – Other specified sickle cell disorders or other haemoglobinopathies
  • 3A51.Z – Sickle cell disorders or other haemoglobinopathies, unspecified

Foundation entity

Haemoglobin C disease – http://id.who.int/icd/entity/2097316574

Part of: 3A51: Sickle cell disorders or other haemoglobinopathies › 03: Diseases of the blood or blood-forming organs